Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers
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منابع مشابه
Association of miR-146a rs2910164 and miR-27a rs895819 polymorphisms with type 2 diabetes susceptibility: A Meta-Analysis
Background and Aim: Several investigations have evaluated the association of miR-146a rs2910164 and miR-27a rs895819 single-nucleotide polymorphisms with susceptibility to type 2 diabetes (T2D). However, the findings are conflicting and inconclusive. Therefore, this meta-analysis performed to investigate the association between these polymorphisms and T2D risk. Methods: Studies were identifie...
متن کاملAssociation of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer
The incidence of endometrial cancer, a common gynecological malignancy, is increasing in Japan. We have previously shown that the ER/MDM2/p53/p21 pathway plays an important role in endometrial carcinogenesis. In the present study, we investigated the effects of germline single nucleotide polymorphisms in murine double minute 2 (MDM2) SNP309, TP53 Arg72Pro, ESR1 PvuII and XbaI, and p21 codon 31 ...
متن کاملInteractions of miR-34b/c and TP53 Polymorphisms on the Risk of Intracranial Aneurysm
Several lines of evidence indicate that inflammatory processes play a key role in the happening and development of intracranial aneurysm (IA). Recently, polymorphisms in the TP53 gene were shown to be associated with inflammation and inflammatory disease. The aim of this study was to investigate the interactions of miR-34b/c and TP53 Arg72-Pro polymorphisms on the risk of IA in a Chinese popula...
متن کاملLack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome.
MDM2/p53 pathway plays an important role in the control of apoptotic and proliferation mechanisms, and alterations in this pathway have been described in myelodysplastic syndromes (MDS). We investigated the frequency of MDM2 SNP309, TP53 Arg72Pro polymorphisms in de novo MDS and the association of these polymorphisms with clinical characteristics. Our results showed that the frequencies of geno...
متن کاملPolymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer.
The microRNA (miR)-34 family is a direct transcriptional target of tumor-suppressor TP53 and loss of miR-34 function may impair TP53-mediated cell cycle arrest and apoptosis. In the present study, we investigated whether the single nucleotide polymorphisms (SNPs) rs4938723 (T>C) in the promoter region of miR-34b/c and Arg72Pro (G>C) in codon 72 of TP53 are independently or complementarily assoc...
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ژورنال
عنوان ژورنال: Translational Oncology
سال: 2019
ISSN: 1936-5233
DOI: 10.1016/j.tranon.2019.06.008